Endocrine Abstracts

Introduction: Nelson´s Syndrome is defined as the presence of an enlarging pituitary tumor associated with elevated fasting plasma ACTH levels and hyperpigmentation in patients submitted to bilateral adrenalectomy for the treatment of Cushing´s disease. Case Report: We present a case of a 48 y/o woman who in 2015, was diagnosed of Cushing’s disease and underwent transsphenoidal adenomectomy but remission was not achieved, so the patient wa...

Introduction: Neutropenia can indicate infectious and hematological pathology but it can also be a sign of hyperthyroidism. For this reason, it has been suggested to perform a complete blood count before starting treatment with antithyroid drugs in case of new-onset hyperthyroidism. Antithyroid drugs can cause severe neutropenia, also called agranulocytosis, when the neutrophil count is less than 500/µl. Therefore, the use of these drugs should be reconsidered if it is le...

Introduction: The presentation of new onset hyperandrogenism is extremely rare in postmenopausal women. In premenopausal women, the most common cause of androgen excess is polycystic ovary syndrome. In contrast, when hyperandrogenism develops in postmenopausal women, it is usually associated with other causes, such as ovarian hyperthecosis or an androgen secreting tumor. We describe 5 patients with hyperandrogenism (Table 1). Total Testosterone 0.06–0.86 ng/ml, free testo...

Introduction: Central diabetes insipidus (DI) is a common complication after pituitary surgery, but is transient in the majority of patients. The aim of our study is to determine the incidence and course of DI in the postoperative period and to characterize the factors associated with this disease.Methods: We performed a retrospective study of 44 patients (50% females) with a mean age of 54 years (24–83), treated with transsphenoidal (TSS) or transf...

Introduction: Ectopic Cushing’s syndrome (ECS) is due to ACTH secretion of no pituitary neuroendocrine tumors and represents around 5–10% of all cases of ACTH dependent Cushing’s syndromes.Methods: Six cases of ECS diagnosticated from 2008 to 2017 were studied. Patients’ age ranges from 36 to 69 years (mean 53), four females and two males. Three had pancreatic tumors, two small cell lung carcinomas and one pheocromocytoma. At diagnosi...